Utility of Biomarkers for Postpartum Hemorrhage Transfusion Requirements Relating to Amniotic Fluid Embolism

Background: We aimed to evaluate the utility of C1 esterase inhibitor, squamous cell carcinoma antigen, and complements C3 C4 in prediction fresh frozen plasma transfusion requirements postpartum hemorrhage characterize involvement amniotic fluid embolism pathophysiology hemorrhage. Methods: In this single-centered prospective observational study, consecutive patients with were evaluated for C4. analyzed relationship between volume above-mentioned biomarkers. The interaction low inhibitor antigen respect was analyzed. Results: analysis included 132 univariate analysis, (correlation coefficient: –0.368, p < 0.001), –0.376, 0.001) –0.291, negatively correlated volume. multivariate only an independent factor associated (regression –0.173, = 0.022). had highest area under curve (0.843) cut-off value (80 mg/dL) ≥15 units. higher high analysis. Conclusions: Measuring may allow assessment extent anaphylactoid reaction requirement transfusion.